Mehta V, Russin J, Spirtos A, He S, Adamczyk P, Amar A, Mack W. Matrix
Neurology Research International, vol. 2013.
Take home 1
C5 deficient mice demonstrate decreased white matter ischemia in the corpus callosum
Take home 2
C5 complement protein may play a critical role in mediating white matter injury
Take home 3
C5 may mediate inflammation in the setting of chronic cerebral hypoperfusion.
Take home 4
Astrocyte and microglial activation within the corpus callosum suggests an inflammatory process