Hypoperfusion and Immunoneurological mechanisms
Pate A, Moalem A, Cheng H, Babadjouni R, Patel K, Hodis D, Chandegara D, Cen S, He S ,Liu Q.
Neurological Research. Aug 22, 2017.
Take home 1
C5 deficient mice demonstrate decreased white matter ischemia in the corpus callosum
Take home 2
C5 complement protein may play a critical role in mediating white matter injury
Take home 3
C5 may mediate inflammation in the setting of chronic cerebral hypoperfusion.
Take home 4
Astrocyte and microglial activation within the corpus callosum suggests an inflammatory process